منابع مشابه
Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma.
BACKGROUND Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk of carcinoma in both breasts. However, the frequent association of LCIS with invasive lobular carcinoma (ILC) suggests a precursor-product relation. The possible genomic relation between synchronous LCIS and ILC was analyzed using the technique of array-based comparative genomic hybridization ...
متن کاملMixed apocrine/endocrine ductal carcinoma in situ of the breast coexistent with lobular carcinoma in situ.
An unusual mixed form of ductal carcinoma in situ (DCIS) of the breast is described, which exhibits a biphenotypic morphology encompassing a range of differential diagnostic DCIS subtypes. In addition, immunophenotypic and ultrastructural studies demonstrate neuroendocrine and apocrine differentiation, raising questions regarding appropriate classification and biological behaviour. In two cases...
متن کاملRecommendations for women with lobular carcinoma in situ (LCIS).
Atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) represent a spectrum of breast disease referred to as "lobular neoplasia" (LN). Although LN occurs relatively infrequently, it is associated with an increased risk of breast cancer, ranging from a three- to four-fold increased risk with ALH up to an eight- to ten-fold increased risk with LCIS. Initially regarded as a direct...
متن کاملThe challenges of treating lobular carcinoma in situ.
Oppong and King present a clear and concise review of the current data regarding lobular carcinoma in situ (LCIS) and discuss the rationale behind the current management recommendations for this disease. It is interesting to note that in 2011 we are still debating the clinical management of LCIS despite these lesions having first been recognized in the early 1900s.[1] Recent advances in genomic...
متن کاملGenetic relation of lobular carcinoma in situ, ductal carcinoma in situ, and associated invasive carcinoma of the breast.
AIMS The mutual relation of lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS) of the breast, as accepted precursor lesions of invasive breast cancer, is controversial. Because they display genetic heterogeneity, it is not clear how genetically advanced these entities are and what causes the transition to an invasive carcinoma. METHODS Six cases of LCIS, four of them with as...
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ژورنال
عنوان ژورنال: Surgical Pathology Clinics
سال: 2018
ISSN: 1875-9181
DOI: 10.1016/j.path.2017.09.009